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Some current information that may help 

in your decision making

Posted 11/07

Drugs as anti-nutrients

Margaret Moss a

a MA (Cantab), UCTD (Manchester), DipION, CBiol, MIBiol, Director of the Nutrition and Allergy Clinic, 11 Mauldeth Close, Heaton Mersey, Stockport, Cheshire SK4 3NP

Abstract

Purpose: To collate evidence on nutrient deficiencies caused by drugs.

Design: Search of Medline and other databases, and published literature.

Materials and methods: Medline, Scirus and Google Scholar databases, journal articles and books.

Results: There is evidence that many drugs, medicinal or recreational, produce deficiencies in vitamins, minerals, fatty acids and/or amino acids. Some drugs cause multiple deficiencies.

They may reduce conversion of vitamins to their active forms, or inhibit the production of important metabolites. By killing beneficial bacteria in the gut, they may cause vitamin deficiency. They may reduce absorption, or cause excretion of nutrients.

Conclusions: Many drugs have been identified, which appear to cause deficiencies in essential nutrients and their metabolites. Nutrients could be prescribed with drugs, to limit the damage done, provided that this does not undermine the action of the drugs.

Further research is needed to confirm the results of those studies that have been carried out, and to find out about nutrient depletion from new drugs.



6/03 Consumers can NOW report adverse drug effects directly to FDA.

http://www.fda.gov/medwatch/report/consumer/consumer.htm

Many pieces of new information are tossed out by researchers. Maybe your health care provider has read about these items, maybe not. Since it is YOUR LIFE, you need to know. The Project believes that information is power.

Check out what interests you.

These pieces come from conferences and studies.

Some suggestions for ways to handle unwanted effects can be found in our section (Studies then Non-Toxic...)


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padBone Mets/Bone Density/Loss
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June 2000 presentation at the International Congress on Bone Metastases
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5-Year Prevention Study Results
Osteonecrosis of the Jaws-Bisphophonate Use
#2986 Chemo Causes Loss of Bone Mineral Density
Safety & Efficacy of Bisphosphonates
Bone Size Matters as Much as Density
Int'l Bone & Mineral Soc/Euro Calci Tissue Soc
Gentle Vibration Improves Bone Growth
Surgical Treatment for Skeletal Mets from Bca
FDA Approves Zoledronic Acid
Aredia Cuts Hormone Thpy Bone Loss-Prostate
Bone Mass & Vit D Deficiency
Laser-Induced Thermotherapy & Mets
Cryosurgery & Bone Metastases
BMT:20 yrs later Immunity Almost Normal
Osteopathic Effect of Bca Chemo
Clodronate & Primary Operable Bca
Back Exercises & Spine Fractures
Site of Bone Mets & Prognosis:Prostate Ca
Treatment for Male Osteoporosis
Phyto-estrogens & Osteoporosis: Safe Dose?
Nutritional Considerations in Osteoporosis:Review
One-Time RTx Eases Bone Pain (NOT TWO WEEKS)
Olive Oil & Phenols Prevent Inflammation (Ovariectomised Rats)
Dietary Calcium vs Supplements
Tea drinking associated w/benefits on bone density in older women
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padAdj Therapy & Cognitive Function
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Study in Journal of Clinical Oncology shows there is "chemo brain" 7/00
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Other Studies On Chemo Brain
Neuropsychologic Impact of Standard Dose Systemic Chemo
Subtle Cognitive Deficits Remain
Radiation Induces Neural Precursor-Cell Dysfunction
Current Knowledge/Research Directions-Bca
Diet in Cognitive Decline
Vitamins E & C: Cognitive Function
Abnormal Regional Brain Metabolism After Chemo
Card Game Tests Cognitive Functions
Cognitive Functioning Before Chemo: BCa
Physical Activity, Walking & Cognitive Function: Older Women
Long-term Cognitive Deficits/Dementia From Cancer
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padRadiation Issues
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8/29/00 Journal of Surgical Oncology
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RADIATION Issues:BCa
Radiation:Cure or Cause-Dr.John Gofman
Erythropoietin /Anemia Drugs:WORSE Survival
Angiostatin May Enhance RTx Effects
Radiotherapy Benefit or Not?
Low-Dose Radiation Can Be Trouble
RTx & Rectal Ca
Radiation/Prostate/ LUNGS
Radiation Damage Through Generations (MICE)
RTX Not Good w/other diseases
Lung Injury From Ionizing Radiation
Alice Stewart -Warnings on Radiation
Wound Complications & Radiotherapy:Sarcoma
Protective Effects of Boerhaavia diffusa L. Against Radiation—Induced Damage
Husband/Activist:Whole Brain RTx
Healing Radiation Scars - Pentoxifylline
Cardiovascular Complications of Cancer Therapy
Technique Changes Reduce Radiation from CT Scans
New standards needed for radiation therapy
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padChemotherapy Issues
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Various articles
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Pre-treatment: Dietary Supplements/Cisplatin
Value of Anthracyclines Questioned
Early Stage Colon Cancer/Chemo (Patient perspective)
Prognostic Disclosure: Near End of Life
Protective effect of hawthorn extract:cyclophosphamide (Mice)
Second & Next Chemo: What do we KNOW?
Chemo-induced Toxicities Reviewed
Antioxidants in Cancer Therapy-Review of Literature
Lung Ca Chemo MORE Costly, No Diff in Survival
Oral Oncology Products
Lancet: Comparison of Chemo for Colon Ca
Less Cycles of CMF (adj chemo)
Opening Line of this Paper tells a Sad Tale
Cancer Medicine's Dark Corners
Carcinomatous Menigitis:Taxane Induced?
Acute Myeloid Leukemia:Doxi & RTx
Circadian Timing of Cancer Chemotherapy
Taxanes in Adj Early Stage Bca
Excessive Tearing & Canalicular Blockage:Docetaxel
Effects of Black Cohosh on Chemotherapies
Chemo for Brain Mets Based on Chemosensitivity of Tumor
Severe Hepatic Sinusoidal Obstruction W/ Oxaliplatin
Bowel Perforation & Fistula Formation W/Bevacizumab
Chemo-induced Diarrhea & Dosing Intensity
PABA Enhances Conventional Cancer Therapies
High-dose Chemo and Cell Support
HER2 & Response to Paclitaxel in Node-Positive Breast Cancer
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padAre Clinical Trials Really The Answer
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Journal of Clinical Nutrition, 1995 Discussion on trials and nutrition
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Informed Consent Not Always Given
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padThrombotic Complications w/Central Venous Catheters
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The Oncologist, 4/04
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padDecision-making on Adj Chemo
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J Clin Onc, 12/03
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Lymph Node Neg & Chemo-Identify Who Benefits
Gene Test for BCA Pts May Help Avoid Chemo for Some
Factors Assoc w/Extreme Drug Resistance Assay (Bca)
Why Chemotherapy May Lead To Cancer
Test to Predict Chemo Response
How to Calculate the Dose of Chemotherapy
Collagen Gel Droplet to Predict Cell Kill
Absolute #s BEST for Discussing Treatment Options
Novel Gene Analysis May Reduce Unnecesary Chemo
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padLow-Dose "Metronomic" Chemo
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Excerpts Robert S. Kerbel, Ph.D. University of Toronto
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Conclusions
Metronomic Dosing of Cytotoxic Drugs in Mice
G. Klement , Ontario Canada on Metronomic Dosing
Patient Perspective from Sybil Brabner
Differences in Therapeutic Indexes
Low Dose Oral Methotrexate & Cycophosphamide
Dana Farber has Metronomic Type Trial
Hyperthermia & Metronomic Chemo:Rat Mammary Ca
Anti-ANGIOGENIC Basis:Metronomic Chemo
AVASTIN Alert Issued
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padLung Cancer: Studies and Issues
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Surgery results
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Equal Survival:Shorter Chemo Course
Influence of Hospital Volume on Survival After Resection
RadioFrequency Ablation Surgery
Herbal Medicine
Risk of Death & Postop Radiotherapy
CT Scanning: Lung CA
Iressa:Cause of Death in Lung Cancer Patients
Celecoxib, Medroxyprogesterone, Dietary :Lung Ca
PET Shows Radiation-induced Changes to Lungs
Risk factors for acute esophagitis: Non-small cell Lung Ca
Ä-9 Tetrahydrocannabinol inhibits growth & metastasis of lung cancer
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padLiposome vs Standard Doxorubicin
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J Clin Oncol, March 2001 Breast cancer pts-6% v 21% cardiotoxicity
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Early Cardiac Damage from Epirubicin
Cardiovascular Trials:Long-term Childhood Survivors
Skin Toxicity with Liposomal Doxorubicin
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padExternal Beam Radiation Impairs Arteries
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J Am Coll Cardiol, March 2001
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Radiation Affects Tiny Blood Vessels
X-Rays and Airplane Travel-Dr.J. Gofman et al
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padAccelerated Chemo/Standard Doses
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J Clinical Oncology. April, 2001
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Patients' Expectations & Nausea from Chemo
Reality of Nausea/Vomiting: Pt perspective differs
Chemo-Induced Vomiting (BCa Pts)
Nausea Relief
Anti-Vomiting Component Isolated
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padChemo in Animals
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J Cancer Research 4/01 (Animal study)
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Peripheral Pain Responses to Paclitaxel (Rats)
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padLiver Problems Caused by Chemotherapy
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The Oncologist, Vol6, No.2, April, 2001
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References
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padNoncardiogenic Pulm Edema-Chemo Complic
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The Oncologist, 4/01
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padFood Intake/Bioavail & Efficacy
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Euro J Cancer, 3/02
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Grapefruits & Their Juice
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padPhotoDynamic Therapy
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Presented at Am Assoc of Neurological Sciences, April 2001
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PDT & Esophageal Dysmotility
Effective Antitumor Vaccine w/PDT
PhotoDynamic Therapy For Prostate
PhotoDynamic Therapy for NSCLC
Indole-3 Acetic Acid Enhances PDT
Luciferin as photosensitizing Agent
Neoadj Photodynamic Therapy for Hilar Cholangiocarcinoma
Advanced CaTreatment Ctr - Xytos (Photodynamic Therapy)
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padProstate Treatment Issues/Studies
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Various articles
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Specialists Steer (Prostate)Pts To Own Therapies
Benefits/Downside of Prostate Ca Therapies
Observation as Management is Right for Some
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padScans
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Reuters Health article, May 2001
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Magnetic Resonance Spectroscopy (MRS)
Protein Packaging to Enhance MRI Contrast
Bca Mortality Higher in Radiation Techs
Abdominal CT Dose Should Vary by Size
Pineapple Juice as Negative Oral Contrast Agent MRI
Warm Blanket Reduces Chance of False Positives: PET Scans
Milk as a Contrast Agent for CT Scans
Are CT Scans Safe?
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padCampath Approval Deaths in Trial
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Reuters Health article,May 7, 2001
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padCardiac Damage
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JCO, May 2001
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Doctors' Guide Review of this Study
Cardiac Effects:Adj Chemo & Radiation
High Incidence of Central Nervous System Involvement
Effects of Dose-Intensive Chemo/Radiotherapy
Cardiotoxic Potential of Anti-Emetics (5-HT3)
Periodontal Infection & High-dose Chemo
Cardiac Peptide Gives Early Warning of Injury (Bca treatment)
Doxorubicin Riskier for the Heart
Gated Heart Test & Others Before Chemo
Gleevec Can Cause Heart Failure
Long-Term Cardiac Trouble & Adjvt Chemotherapy
Cardiovascular
Heart failure associated with sunitinib
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padToxic  Drug: Camptosar (irinotecan)
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NEJM notified, May 2001
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St. John's Wort Weakens Camptosar's Effects
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padRadiotherapy Problems:Brain Cancer Pts
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Neurology, May,2001
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padSurvival Patterns
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J Cancer, 6/01
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Polychemo-randomized overview
Chemotherapy: Long Term Results
Overview of Chemotherapy Effects in Bca
Discussion on "choosing" Chemo
Second Cancers After Treatment
Therapy/Survival Ewing's Tumors
Cytotoxic Chemo 5-yr Survival Adults
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padWomen and Anesthesia
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Medical J of Australia, 9/01
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padLiver Metastases & Liver Tumors
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9/17/01 Doctor's Guide on Italian study
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Electrolysis of Liver Tumors
Effective Therapy Lacking for Resectable Hepatocellular Ca
Prognostic Factors for Bca w/Liver Mets
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padQOL & Anterior Resection Rectal Ca
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Br J of Surg, 9/01 FYI for Patients
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Evaluation of Policy of Total Mesorectal Excision
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padThalidomide Label Warns of Seizure Risk
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Reuters Health, 9/11/01
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Management of Thalidomide Adverse Effects
Thalidomide Associated with Thromboembolic Events
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padPre-Op Chemo-Survival No Better
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Doctor's Guide
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padDNA Much More Important than Ethnicity
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Nature News Service, 10/01
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Race & the Clinic: Good Science?
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padNatural Protein Helps Prevent Spread of Ca
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Am Chem Soc, 11/01
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padPancreatoduodenectomy Study
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Brit J Surg, 2001
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padDuodenal Disease & Prophylactic Colectomy
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Gastroenterology, 2001
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padRalph Moss comments on Gleevec
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12/01 Ralph Moss'comments and some quotes from Oncology Times
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Leukemia Gene Morphs & Evades Gleevec
Severe Cutaneous Reactions to Gleevec
BMS-354825 For Gleevec-resistant CML
Altered bone & mineral metabolism in patients Gleevec
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padLacrimal Duct & Ocular Toxicity from CMF
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Clincal Oncology, 12/01
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BOOK: " A Singular View The Art of Seeing with One Eye"
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padBca & Meningioma
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Jpns J Clinical Oncology, 12/01
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padSurvey of Toxicity Assess & Reporting
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J Clin Oncol, 1/02
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Unable to Eat Due to Treatment
Unwanted Effects From Anti-Nausea/Vomiting Drugs
Documented Allergies in People w/Cancer
Dexamethasone Reduces Paclitaxel/Doxorubicin Effects
Desensitization from Hypersensitivity Reactions to Chemo
Epidermal Grwth Factor Rcptor Inhibitor–Assoctd Cutaneous Toxicities:
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padValue of  Cancer Screening
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JNCI 2/02
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Breath Test To Dectect Ulcers (linked to Cancer)
Possible Blood Test for Colon Cancer
Hand Held Device May Detect Cancer
Diagnsotic Imaging Technique:3TP
Pilot Study: Canine Scent Detection Lung/Breast Ca
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padSurgical & Node Issues
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J Surg Oncol, 2/02
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Second Colorectal Cancers Develop Despite Follow-up Tests
Management of Regional Lymph Nodes
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padSecond Opinion A Necessity
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blochcancer.org, ABC News
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Pathology Second Opinions
Interobserver Variability: Pathology
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padProzac Linked To Cancer Growth
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The Scotsman scotsman.com
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padWays to Prevent Medical Errors
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Nat'l Council on Patient Information & Education
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padEndostatin-Phase I Success
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J Clin Oncol, 9/02
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padTumorigenesis: Clockwork
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J Cell, 10/02
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Cancer Clocks as Therapy Target
Circadian Rhythms' Effect on Immune Cells: Chemo TOXICITY
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padHelp w/Prescriptions-Convtl Meds
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Pharmaceutical & Manufacturer's Association program, 3/03
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Up to 1.9 Million Adverse effects-180,000 FATAL
Partnership for Prescription Assistance
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padCrysosurgery
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Cancer, 5/03
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Freezing Tumors Effective Pain Treatment
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padUnderstanding the Language of Cancer
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Intelihealth.com, 6/03
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padPatients May Overestimate Unwanted Effect Risks
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Lancet, 3/02
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Determinants of Chronic Fatigue in Disease-free Pts
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padCancer Discovery Would  By-Pass Chemo
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J Molecular Cell, 6/03
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padAlleviating Anemia: Pts Receiving Chemo
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Oncology, 10/02
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Procrit Trial Halted:BLOOD CLOTS
Erythropoietic Agents as Neurotherapeutic Agents:Barriers?
QoL Benefit w/Epoetin Alfa: Many Tumor Types
Study Finds NO Clinically Significan Diff (Anemia)
Erythropoietin (EPO) during radiation treatments BAD
Pure Red Cell Aplasia from epoetin alfa
Aranesp (Darbepoetin Alfa)
Lilla Romeo, Pt Advocate Quoted on Limits to Anemia Drugs
New Studies on Anemia Drugs' RISKS - FDA
Leading Edge: Erythropoietin analogues UNNECESSARY...
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padRadiofrequency to Ablate Solid Tumors
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Several studies show efficacy, non-toxic - acceptance slow
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Liver Cancer and Radiofrequency Ablation
Radiofrequency Thermal Ablation/Tumor Therapy
Radiofrequency Ablation (RFA) for Kidney Tumors
RFA and Complete Necrosis of Invasive Bca
Ablation Increases Value of Liposomal Chemo
Radiofrequency Energy Can Kill Solid Tumors in Kidney
Radiofrequency ablation therapy in pts with small breast ca
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padHospitalized Ca Pts w/ Severe Sepsis - Analysis
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Critical Care, 6/04
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padGel-based Drug Delivery May Avoid Injections
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J Polymer International, 9/04
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padCircadian Rhythm, Lung Function & Exercise
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UPI, 10/04
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TIMING of Surgery/Chemo, etc.
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padAnti Cancer Virotherapy - natural virus used
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Press Release, 3/14/05 Presented at 3rd Intl Meeting on Replicating Oncolytic Virus Therapeutics
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padMeta-analysis: Statins & Cancer Risk  - NO REDUCTION
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JAMA. 1/06
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padBlood Test Detects Cancers
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Thanks to Doctors' Guide and Mid Hudson Options Project
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FDA Clears Test: Identify Type of Ca in Tumor Sample
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padMUSHROOM Phellinus linteus works w/Doxorubicin
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British J Cancer,

Posted 9/06
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Phellinus linteus Induces Apoptosis in Prostate Ca Cells
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padFuture Cancer Risk for Stem Cell Transplant Patients
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Cancer (online), 11/06
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padVaccines
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Various articles, all types of cancer and vaccines Posted 7/07
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